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Process Development Engineering, Senior Scientist - Media Development

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Posted on: 15 Mar 2024

Job Location: Oklahoma City, US

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locations

Boston, MA

time type

Full time

posted on

Posted 2 Days Ago

job requisition id

REQ-21554

Job Description
Vertex has established a site in Boston Seaport where research, development, and clinical manufacturing for cell and genetic therapies are primarily based. Cell and genetic therapies represent two rapidly emerging therapeutic modalities with the potential to treatand even cureseveral of the diseases Vertex is focused on, including sickle cell disease, Duchenne muscular dystrophy and type 1 diabetes. Further investment in the site specifically designed to advance these programs will be key to Vertexs continued and sustained leadership in these exciting approaches. At Vertex Cell and Genetic Therapies (VCGT) our teams will bring together the best biology, technologies, and enhanced manufacturing capabilities to ensure we bring

these cutting-edge

transformative therapies to patients as quickly as possible.

VCGT is seeking a Senior Scientist to lead the media development effort in our Process Development Engineering team. The focus of this position is to lead cell culture medium development and optimization for cell and gene therapy applications, with a high performing team. The position will be based in Boston, MA.
Duties and Responsibilities:
Lead the design and execution of experiments, together with the team, to evaluate new medium components and supplements, confirm the cell culture performance.
Align with leadership to develop strategic roadmap on continuous medium optimization and phase-appropriate medium development and implementation.
Manage the medium development team to ensure timely delivery of cell culture medium development and optimization projects.
Lead the establishment and utilization of high throughput small scale screening platforms. Apply Design of Experiment (DOE) principles for medium development and optimization.
Bring innovation to the team, contributing novel ideas and solutions to address challenges and improve processes.
Lead by example, work closely with the team in the lab and conduct hands on experiments.
Collaborate with cross-functional teams, aligning on project goals, sharing results, and fostering a collaborative working environment.
Ensure data integrity by timely completion of phase-appropriate documentations, including experiment recording in electronic notebook system, develop protocols, and author reports to support future technology transfer and regulatory filings.
Ensure compliance on lab safety procedures.
Empower and support junior team members to independently plan and design experiments. Continuously grow and encourage team members on scientific and critical thinking.
Minimum Requirements
Degree in Stem Cell Biology,

Chemical/Biochemical/Biomedical

Engineering, Life Sciences, or related discipline.
PhD with a minimum of 2-5 years of relevant industry work experience, or a BS with 8+ years of industry experience, or an MS with 6+ years of relevant industry experience.
Strong fundamental knowledge and previous experience of medium development and mammalian cell culture (stem cell culture knowledge and experience is preferred) as well as knowledge of recent advances and challenges in the field.
Experience on high throughput automation platforms for medium and process optimization, as well as DoE principled experimental design and execution.
Strong fundamental knowledge and experience on bioreactors across scales.
Must have a working knowledge of cGxP.
Excellent verbal and written communication skills.
Ability to handle multiple tasks while meeting timelines and adapting to changing priorities.
Excellent organizational skills and high attention to detail.
Participate in weekend work rotation with the broader team.
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Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at

[email protected].
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Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases cystic fibrosis, sickle cell disease and

transfusion-dependent

beta thalassemia and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency

.
Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortunes 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit

www.vrtx.com

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Facebook

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,

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,

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.
The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change peoples lives.
Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.

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